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pentobarbital will lessen the level or result of ambrisentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.pentobarbital will decrease the extent or impact of theophylline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the level or impact of almotrip